La méta-analyse d’Alberto Zanchetti fera sans doute date dans l’histoire de l’HTA car elle permet de fixer les connaissances concernant les risques liés à l’HTA et les moyens de les prévenir par les médicaments antihypertenseurs.
La British Heart Foundation a réalisé un programme d’essais thérapeutiques appelé PATHWAY (Prevention And Treatment of Hypertension With Algorithm based therapY). Son objectif était de comparer l’efficacité sur la baisse de la pression artérielle de l’usage des diurétiques à différents étapes de la prise en charge de l’HTA.
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